Abstract
Background and purpose. The aim of this work is to evaluate the efficacy of treatment patients with moderate left-sided and total ulcerative colitis (UC) with prolonged-release ethylcellulose-coated mesalazine. Materials and methods. The clinical analyses of results of treatment UC patients with prolonged-release ethylcellulose-coated mesalazine was performed. Eighty-seven patients with UC, treated with ethylcellulose coated microgranules of mesalazine, were examined: 38 (43,7%) men and 49 (56,3%) women. The age of patients was from 26 to 49 years, median age 38,3±12,6 year. Results. After 2 weeks prolonged-release ethylcellulose coated mesalazine treatment the response to therapy was demonstrated in majority of UC patients -71 (81,6%). After 12 weeks treatment prolonged remission persisted in 71 (81,6%) UC patients. Mayo score decreased from 7,6±0,99 to 2,6±0,25 points. Significant decrease of inflammation markers (CRP, ESR, leukocytosis, fecal calprotectin etc) was determined. After 26 weeks of treatment Mayo score was 2,2-2,3 points. Thirty-two (36,8%) UC patients showed healing of colon mucosa. After 1 year of prolonged-release ethylcellulose-coated mesalazine treatment clinical remission was determined in 69 (79,3%) UC patients with response to therapy, clinical-endoscopic remission — in 32 (36,8%) patients. During 1 year follow-up no cases of surgical procedure and readmission because of UC reccurence were noted. Conclusion. Treatment of moderate active UC should be started with oral mesalazine > 3 gr per day and rectal mesalazine. The most appropriate effective and high compliance forms of mesalazine are prolonged-release forms of meselazine.
For citation: Knyazev OV, Kagramanova AV, Veselov AV, Shkurko TV. Effectiveness of treatment moderate ulcerative colitis with prolonged-release ethylcellulose-coated mesalazine in real clinical practice in Moscow. City Healthсare. 2021; 2(2): 65-74. doi: 10.47619/2713-2617.zm.2021.v2i2;65-74
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Author Biographies
Oleg V. Knyazev , “Moscow Clinical Scientific Center named after A. S. Loginov” MD, Рrofessor, Head of the Department of Treatment of Inflammatory Bowel Diseases of the “Moscow Clinical Scientific Center named after A. S. Loginov”; Specialist of the Department of Coloproctology of the State Budgetary Institution “Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department”; Professor of the Scientific and Еducational department of the Federal State Budgetary Institution “National Medical Research Center of Coloproctology named after A. N. Ryzhikh”
Аnna V. Kagramanova , “Moscow Clinical Scientific Center named after A. S. Loginov” Candidat of Medical Sci., Senior Research Associate
Alexey V. Veselov , The State Budget Institution “The Research Institute of Health Care organization and Medical Management of the Moscow Health Care Department”, 115088, Moscow, Russia senior specialist of the Organizational and Methodological Department of Coloproctology
Tatyana V. Skurko , State Budget Institution “The Research Institute of Health Care organization and Medical Management of the Moscow Health Care Department”, 115088, Moscow, Russia Candidat of Medical Sci., Head of the Organizational and Methodological Department of Coloproctology
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